EXTRACTS OF PSORALEA COYLIFLIA WITH HIGH-ESTROGENIC ACTIVITY OR FORMULA CONTAINING FUNCTIONAL COMPONENTS FROM ITS EXTRACTS

摘要

Psoralea coyliflia extracts with high estrogenic activity or a composition containing active components separated from the Psoralea corylifolia extracts are provided to replace a hormone replacement therapy which administers estrogen by using a natural product. A method for separating active components from Psoralea corylifolia extracts comprises the steps of: (i) extracting Psoralea corylifolia alcohol solvent extract with dichloromethane; (ii) performing silica gel column chromatography that makes the dichloromethane/methanol solution in Psoralea corylifolia dichloromethane extracts mobile to obtain the first fraction or the eleventh fraction; and (iii) performing silica gel column chromatography that makes normal hexane/ethylacetate in the third fraction among 11 fractions mobile to obtain 10 fractions from 3-1 to 3-10, and vacuum concentrating 3-2 fraction to obtain bakuchiol.