发明名称 |
USE OF NEUREGULIN-1 IN REDUCING BRAIN DAMAGE |
摘要 |
<p>Methods of reducing and/or protecting against disorders in perinatal subjects are disclosed. Such methods can be used for disorders associated with neuronal cell damage. In certain aspects, the method comprises administering a therapeutically effective amount of neuregulin or a biologically active analog with a pharmaceutical carrier to a perinatal subject. In addition, the perinatal subject can be a fetus where the neuregulin is administered to the pregnant mother. Methods for assessing whether a perinatal subject is at risk for developing a neurological disorder are also disclosed. For example, expression levels of neuregulin can be used as an indication the perinatal subject is at risk for developing a disorder associated with neuronal cell damage. Evaluating the genotype of the NRG locus in a perinatal subject can also be used as an indicator of the risk of developing neurological disorders.</p> |
申请公布号 |
WO2009046453(A2) |
申请公布日期 |
2009.04.09 |
申请号 |
WO2008US78995 |
申请日期 |
2008.10.06 |
申请人 |
NEW ENGLAND MEDICAL CENTER (NEMC);DAMMANN, CHRISTIANE, E.L.;DAMMANN, OLAF |
发明人 |
DAMMANN, CHRISTIANE, E.L.;DAMMANN, OLAF |
分类号 |
A61K38/18;A61P25/00;C07K14/47 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|