| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a mass-producible ACE inhibitor composition etc., having excellent ACE inhibitory activity, producing anti-hypertensive effects without problems in aspects of safety such as adverse effects or toxicity and having excellent organoleptic evaluation when added to a food without complicating a method for preparation. <P>SOLUTION: This method for producing the ACE inhibitor composition comprises successively performing a powdery oat defatting step of carrying out a defatting treatment of pulverized oat with an organic solvent, (a) a protein fractionation step of treating the defatted oat powder with amylase, then adding ethanol and sedimenting the protein fraction or (b) a protein fractionation step of adding an alkali salt or an alkaline earth salt solution to the defatted oat powder, homogenizing the resultant mixture and carrying out a desalting treatment of the resultant eluted fraction and an oat protein hydrolyzing step of hydrolyzing the oat protein fraction with pepsin and trypsin and affording a peptide fraction containing peptides having amino acid sequences of VIEPQGL, NIVQMSATR, VQVVNNNGQTVF and IVPQHF. <P>COPYRIGHT: (C)2009,JPO&INPIT |
