| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a farnesol derivative that is solid at room temperature, because of its high melting temperature, highly soluble in water, and can exhibit the useful action of fanesol in vivo. <P>SOLUTION: The farnesol carboxylate derivative is represented by general formula (1) (where R<SP>1</SP>means a carboxylate residue bearing a nitrogen-substituted group). The farnesol carboxylate derivative can be produced by the esterification reaction between an amino acid bearing a protective group protecting amino, hydroxy, thiol groups or the like and farnesol; or N,N-dialkyl amino acid hydrohalide is used to carry out esterification reaction with farnesol in the presence of an activated esterification reagent. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
