T TYPE CALCIUM CHANNEL BLOCKERS AND THE TREATMENT OF DISEASES

摘要

The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor blocks an a1H isoform of T type calcium channels or a d25 splice variant thereof. The T type calcium channel inhibitor has a structure represented by Formula (I), wherein R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy; X is selected from the group consisting of N and CH; Z is selected from the group consisting of NH, O, S and CH2; R2 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy; and R3 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy. In one embodiment R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy, X is N, Z is O or CH2, R2 is H, halo, NH2 or hydroxy and R3 is H.