发明名称 |
NOVEL CHONDROITIN SULFATE HAVING DECREASED MOLECULAR WEIGHT AND USE THEREOF |
摘要 |
An object of the present invention is to provide a chondroitin sulfate having a decreased molecular weight which has utilization as an inhibitor of peritoneal disorder caused by long-term use of a peritoneal dialysis fluid containing glucose or a polysaccharide thereof as an osmotic agent, utilization as an osmotic agent in a peritoneal dialysis fluid, and the like. The chondroitin sulfate having a decreased molecular weight of the present invention as a means for achieving the object is characterized by having a weight average molecular weight of from 1000 to 20000 and containing a constituent disaccharide unit represented by the following structural formula in an amount of from 65 % to 100 %(molar ratio) of the total. - [4GlcA.beta.1-3GalNAc ( 6S) .beta.1] -(wherein G1cA represents a D-glucuronic acid residue; GalNAc represents an N-acetyl-D-galactosamine residue; .beta.1-3 represents a .beta.1-3 glycosidic linkage; .beta.1-4 represents a .beta.1-4 glycosidic linkage; and (6S) indicates that position 6 of the monosaccharide residue is sulfated) |
申请公布号 |
CA2706254(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
CA20082706254 |
申请日期 |
2008.10.01 |
申请人 |
SEIKAGAKU CORPORATION |
发明人 |
KOJIMA, KAZUHIRO;GOTO, YUKIO;MAEDA, HIROSHI |
分类号 |
C08B37/08;A61K31/737;A61M1/14;A61M1/28;A61P7/08 |
主分类号 |
C08B37/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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