METHOD OF PREDICTING DRUG-INDUCED PHOSPHOLIPIDOSIS

摘要

It is intended to provide a method of predicting drug-induced phospholipidosis which comprises: the step of contacting mammalian cells with a test compound; the step of measuring the amount or activity of a lysosomal enzyme outside and/or inside the cells, or measuring the amount of LC3 in the cells; and the step of selecting a test compound, which promotes the secretion of the enzyme out of the cells or increases the amount of the protein, as a compound capable of inducing drug-induced phospholipidosis.