发明名称 |
Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
摘要 |
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders. |
申请公布号 |
US2009093418(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
US20080285299 |
申请日期 |
2008.10.01 |
申请人 |
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. |
发明人 |
BASSOV TIMOR;BEN-YOSEF TAMAR;NUDELMAN IGOR;REBIBO-SABBAH ANNIE;SHALLOM-SHEZIFI DALIA;HAINRICHSON MARIANA |
分类号 |
A61K31/7008;A61P43/00;C07H17/00 |
主分类号 |
A61K31/7008 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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