PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA

摘要

An object of the present invention is to provide a useful and novel phosphoramidite compound for the synthesis of oligo-RNA. A phosphoramidite compound represented by the following general formula (1),
wherein:
B x represents a nucleobase which may have a protecting group; and
R 1 is a substituent represented by the following general formula (2),
wherein:
R 11 , R 12 and R 13 are the same or different and each represents hydrogen or alkoxy;
R 2a and R 2b are the same or different and each represents alkyl, or R 2a and R 2b taken together with the adjacent nitrogen atom may form a 5- to 6-membered saturated amino cyclic group, the amino cyclic group optionally having an oxygen or sulfur atom as a ring-composing member in addition to the adjacent nitrogen atom; and
WG 1 and WG 2 are the same or different and each represents an electron-withdrawing group.