发明名称 |
METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF STATIN-INDUCED MYOPATHY |
摘要 |
The invention provides compositions and kits containing an atrogin-1 inhibitor compound useful for the treatment of a statin-mediated myopathy. Kits for the diagnosis of a statin-mediated myopathy are also provided. The invention further features methods for treating or preventing a statin-mediated myopathy in a subject via administration of a therapeutically effective amount of an atrogin-1 inhibitor compound. The invention further provides methods of diagnosing a subject as having a propensity to develop a statin-induced myopathy and methods of monitoring a statin-induced myopathy or a propensity to develop a statin-mediated myopathy in a subject. The invention also features methods for identifying a compound for the treatment of a statin-mediated myopathy and methods of identifying a statin compound as having the propensity to induce a statin-mediated myopathy.
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申请公布号 |
US2010310574(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
US20080663423 |
申请日期 |
2008.06.05 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
SUKHATME VIKAS P.;LECKER STEWART H.;HANAI JUNICHI |
分类号 |
A61K39/395;A61K31/675;A61K31/7105;A61K38/02;A61P21/00;C12N5/07;C12Q1/68;G01N33/53;G01N33/566;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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