COMPOSITIONS AND METHODS TO INDUCE DIFFERENTIATION AND GROWTH INHIBITION IN BREAST CANCER

摘要

Compositions and methods for treating triple negative breast cancer or sensitizing triple negative breast cancer cells to treatment are disclosed. The compositions comprise peptides derived from the mSin3A interaction domain (SID) and derivatives thereof, as well as small molecule inhibitors (SMIs) capable of interfering with interactions between SID and the paired amphipathic helix domain 2 (PAH2) domain of the transcription repressor Sin3A.