| 发明名称 |
Novel VIII Factors for the Treatment of Type A Hemophilia |
| 摘要 |
The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.
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| 申请公布号 |
US2010311659(A1) |
申请公布日期 |
2010.12.09 |
| 申请号 |
US20080528379 |
申请日期 |
2008.02.22 |
| 申请人 |
BIOMETHODES;HOSPICES CIVILS DE LYON |
发明人 |
SABOULARD DIDIER;PLANTIER JEAN-LUC;DELCOURT MARC;NEGRIER CLAUDE;MENGUY THIERRY;BLESA STEPHANE;MARIN SYLVIE |
| 分类号 |
A61K38/37;A61P7/04;C07H21/04;C07K14/755;C12N15/63;G01N33/53 |
主分类号 |
A61K38/37 |
| 代理机构 |
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