A first aspect of the invention relates to an apparatus (100) for genotoxicological screening. The apparatus (100) comprises a processor (114) for analysing images. The processor (114) is configured to provide an identifier module (115) for identifying target cells in an image and a dynamically modifiable classifier module (116) for classifying the identified cells in accordance with one or more phenotype, such as micronuclei, for example. The processor (114) is also configured to provide a scoring module (117) for assigning respective confidence measurements to the classified cells. Various aspects and embodiments of the invention may be used, for example, to provide for improved reliability and accuracy when performing automated high-throughput screening (HTS) drug assays.
申请公布号
WO2010139697(A1)
申请公布日期
2010.12.09
申请号
WO2010EP57651
申请日期
2010.06.01
申请人
GE HEALTHCARE UK LIMITED;ALEXANDROV, YURIY;STUBBS, SIMON LAURENCE JOHN