SALINOSPORAMIDE DERIVATIVES AS PROTEASOME INHIBITORS.

摘要

Disclosed herein are 6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione or heterobicyclic γ-lactam-β-lactone derivatives of formula (I) that include a sulfonate ester, ester or ether group in the substituent at the 4-position as proteasome inhibitors. These Salinosporamide derivatives of formula (I) can be included in pharmaceutical compositions and can be used for treating or ameliorating a disease or condition such as cancer, a microbial disease or inflammation.