发明名称 |
MUTANT PROTEINS AND METHODS FOR SELECTING THEM |
摘要 |
A method for selecting a membrane protein with increased stability, the method comprising: a) providing one or more mutants of a parent membrane protein in a membrane-containing composition, wherein the one or more mutants are exposed to an amount of a membrane destabilizing agent which is effective to destabilize the parent membrane protein in-situ, b) determining whether the or each mutant membrane protein has increased stability with respect to its structure and/or a biological activity compared to the stability of the parent membrane protein with respect to its structure and/or the same biological activity, and c) selecting the one or more mutants which have increased stability compared to the stability of the parent membrane protein. |
申请公布号 |
EP2247951(A1) |
申请公布日期 |
2010.11.10 |
申请号 |
EP20090709912 |
申请日期 |
2009.02.05 |
申请人 |
HEPTARES THERAPEUTICS LIMITED |
发明人 |
WEIR, MALCOLM, PETER;HENDERSON, RICHARD;TATE, CHRISTOPHER, GORDON;HULME, EDWARD, CHRISTOPHER |
分类号 |
G01N33/566;C07K14/72;C12N15/10 |
主分类号 |
G01N33/566 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|