发明名称 |
NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST;AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
<p>PURPOSE: A compound as a vinilloid receptor antagonist, an isomer thereof, and a pharmaceutical composition containing thereof are provided to secure the remarkably improved balance of the vinilloid receptor 1 activity and the PK properties. CONSTITUTION: A compound, an isomer thereof, and pharmaceutically acceptable salt thereof has the structure marked with chemical formula 1. In the chemical formula 1, R1 is hydrogen, methyl, or ethyl. R2 and R3 are independently, the hydrogen, halogen, cyano, the methyl, the ethyl, methoxy, trifluoromethyl, vinyl, or acetylenyl. R4 is either the trifluoromethyl or fluoro.</p> |
申请公布号 |
KR20100119757(A) |
申请公布日期 |
2010.11.10 |
申请号 |
KR20107016895 |
申请日期 |
2009.01.28 |
申请人 |
AMOREPACIFIC CORPORATION |
发明人 |
SHIN, SONG SEOK;KIM, JIN KWAN;KIM, SUN YOUNG;LEE, KI WHA;WOO, BYOUNG YOUNG;MOH, JOO HYUN;JEONG, YEON SU;LIM, KYUNG MIN;CHOI, JIN KYU;KOH, HYUN JU;PARK, YOUNG HO |
分类号 |
C07C311/45;A61K31/18;A61P29/00;C07C311/13 |
主分类号 |
C07C311/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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