| 摘要 |
A method for construction of size ranges of solid medicinal forms (SMF), prepared by pressing, preferably tablets, granules, which comprises the selection of shape and construction of SMF size ranges depending on their weightand density, where the construction of SMF size ranges, preferably tablets, granules, without limitation of dimension types convexity degree of side surfaces – from spherical to plane-cylindrical – depending on their weight, density and necessity in incapsulation thereof, is made by shape determination based on single independent determination constant, which determinates a convexo-convex disc habitus for each SMF dimension type and represents the function of a number, which is equal to the golden ratio, and which is determined by the following equation:,,and by two dependent determination constants:,,for each SMF dimension type a range of determination constant change is set and geometry of constructed (selected) shape is calculated based on SMF weightand densityby meas of the equations:,,,H=&bgr;·d,,,,0≤n≤N,N≥1,where- SMF diameter, m;- SMF convexo-convex disc diameter, m;- SMF height, m;- SMF side surface radius of curvature, m;- SMF side surface section circle radius (disc radius), m;- determination constant of SMF side surface convexity;- basic convexity constant of SMF side surface;- SMF diameter determination constant;- SMF height determination constant;- SMF volume, m;- SMF weight, kg;- SMF density, kg/m. |
