| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: method of obtaining dry diketopiperaxine powder includes obtaining diketopiperazine solution, stage of diketopiperazine-containing particles formation and removal of solvent by drying by means of dispersion. Method can include additional stage of loading diketopiperazine particles with active agent, which represents peptide or protein, preferably, insulin. Diketopiperazine preferably is fumaryldiketopiperazine. Diketopiperazine particles, obtained by invention method, possess improved aerodynamic characteristics, active agent, in particular insulin, is more stable and is delivered in more efficient way in comparison with composition of diketopiperazine-insulin, dried by means of sublimation. ^ EFFECT: dry powders are used as compositions of pharmaceutical preparations for delivery in pulmonary way. ^ 16 cl, 10 dwg, 5 tbl, 8 ex |
