发明名称 |
Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines |
摘要 |
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells.
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申请公布号 |
US7807186(B2) |
申请公布日期 |
2010.10.05 |
申请号 |
US20080015116 |
申请日期 |
2008.01.16 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY |
发明人 |
OSTRAND-ROSENBERG SUZANNE;BOSCH JACOBUS J.;KSANDER BRUCE R. |
分类号 |
A61K39/00;C12N5/09 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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