| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to medicinal agents and combination for treatment of respiratory disease, containing (a) efficient amount of 2-agonist selected from group that consists of formoterol and salmeterol not necessarily in the form of their racemic compounds, their enantiomers, their diastereoisomer and their mixtures and their mixtures and not necessarily their pharmacologically compatible acid-additive salts, and (b) efficient amount of antagonist of muscarinic receptors M3, which represents 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azonibicyclo[2.2.2]octane in the form of salt with anion X, which represents pharmaceutically acceptable anion of mono- or polyvalent acid. Also product, set and package are disclosed, which contain (a) 2-agonist and (b) antagonist of muscarinic receptors M3, as well as use of active ingredients (a) and (b) for production of medicinal agent and method for treatment of patient suffering from respiratory disease. ^ EFFECT: reduced maximum frequency of heart contractions and its duration. ^ 19 cl, 3 dwg, 1 tbl, 2 ex |
