发明名称 |
USE OF A TRPM5 INHIBITOR TO REGULATE INSULIN AND GLP-1 RELEASE |
摘要 |
The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor. |
申请公布号 |
EP2107908(A4) |
申请公布日期 |
2011.07.20 |
申请号 |
EP20080725127 |
申请日期 |
2008.02.04 |
申请人 |
REDPOINT BIO CORPORATION |
发明人 |
LEE, S., PAUL;ZHOU, PEIHONG;BUBER, M.N., TULU;CERNE, ROK;BRYANT, ROBERT;SALEMME, F., RAYMOND;MORGAN, GILLIAN |
分类号 |
A61K31/655;A61K31/415;A61P3/04;A61P3/10 |
主分类号 |
A61K31/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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