| 摘要 |
The invention provides a nucleic acid construct for targeting and killing cells infected with the human immunodeficiency virus (HIV). The construct includes an HIV Tat-dependent promoter operably linked to the coding region for a cell-killing protein, such as anthrolysin-O (anlO), which is partially or fully within an intron defined by a splice donor site and a splice acceptor site. The construct further includes a Rev Responsive Element (RRE). Therapeutic methods of treating HIV infection are also provided.
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