Rage fusion proteins and methods of use for treating inflammation

摘要

The use of a RAGE fusion protein in the preparation of a medicament for treating in a diabetic subject inflammation associated with transplantation of islet cells from a non-diabetic subject to the diabetic subject. The RAGE fusion protein comprises a RAGE polypeptide directly linked to a polypeptide that comprises a CH2 domain of an immunoglobulin. The RAGE fusion protein comprises a RAGE interdomain linker rather than an interdomain hinge from an immunoglobulin. The RAGE polypeptide comprises a RAGE ligand binding site.