发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF TAMOXIFEN RESISTANT BREAST CANCER |
摘要 |
The inventors found that the gene, HOXB7, was frequently overexpressed in breast cancer, and is a major upstream regulator of events leading to tamoxifen resistance. The present invention provides double-stranded short interfering nucleic acid (siNA) molecules that targets the HOXB7 gene in cells, and also provides methods of use of this siNA molecule for methods of screening, diagnosis and prediction of treatment outcomes as well as treatment of cancer. |
申请公布号 |
WO2012118915(A2) |
申请公布日期 |
2012.09.07 |
申请号 |
WO2012US27185 |
申请日期 |
2012.03.01 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;SUKUMAR, SARASWATI;JIN, KIDEOK |
发明人 |
SUKUMAR, SARASWATI;JIN, KIDEOK |
分类号 |
C12N15/113;A61K31/7088;A61K48/00;A61P35/00;C12N15/63;G01N33/15 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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