| 发明名称 |
MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A XP GENE AND USES THEREOF |
| 摘要 |
An I-CreI variant which has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG (SEQ ID NO: 229) core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a xeroderma pigmentosum gene. Use of said variant and derived products for the prevention and the treatment of Xeroderma pigmentosum.
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| 申请公布号 |
US2013061341(A1) |
申请公布日期 |
2013.03.07 |
| 申请号 |
US201213560225 |
申请日期 |
2012.07.27 |
| 申请人 |
ARNOULD SYLVAIN;PEREZ-MICHAUT CHRISTOPHE;SMITH JULIANNE;CELLECTIS S.A. |
发明人 |
ARNOULD SYLVAIN;PEREZ-MICHAUT CHRISTOPHE;SMITH JULIANNE |
| 分类号 |
C12N9/16;A01H5/00;A01K67/027;A61K38/46;A61K48/00;A61P17/00;C12N1/19;C12N1/21;C12N5/10;C12N15/55;C12N15/63;C12N15/90 |
主分类号 |
C12N9/16 |
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