PROCESS FOR PRODUCTION OF DFMB DERIVATIVES

摘要

Disclosed is a process for the production of a compound of formula (IotaPi). The process comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent:wherein - n is 0 1, 2, 3 or 4; - X is NH, O or S; - each R] group may be the same or different, and is independently selected from the group consisting of hydrogen, hydroxyl, alkoxy, alkyl, carbonyl, carboxyl, carboxylic acid ester groups, amido, cyano, halogenated aliphatic, nitro, or amino groups; - R2 group is selected from the group consisting of hydroxyl, CI, F, Br, amino or alkoxy.