发明名称 |
ANTIVIRAL SIMILAR MINI-ANTIBODY, NUCLEOTIDE SEQUENCE, EXPRESSING RECOMBINANT VIRAL VECTOR, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR THERAPY OF INFLUENZA TYPE A |
摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to virology and implies using the similar mini-antibodies for the prevention and therapy of influenza. What is declared is a similar mini-antibody specifically binding to a certain epitope of influenza A (H5N2) hemagglutinin and suppressing the influenza A (H5N2) infection. What is created is an adenovirus viral vector expressing the similar mini-antibody, which can effectively bind to the certain epitope of influenza hemagglutinin and thereby block the influenza progression. What is presented is a composition containing an effective amount of the similar mini-antibody and the viral vector expressing this similar mini-antibody.EFFECT: what is presented is a method for the prevention and therapy of the influenza A (H5N2) infection providing administering the preventive or therapeutic effective amount of the pharmaceutical composition intranasally in the form of drops or spray into the patient in need thereof.9 cl, 10 dwg, 2 tbl, 10 ex |
申请公布号 |
RU2536956(C1) |
申请公布日期 |
2014.12.27 |
申请号 |
RU20130136507 |
申请日期 |
2013.08.05 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT PUL'MONOLOGII FEDERAL'NOGO MEDIKO-BIOLOGICHESKOGO AGENTSTVA" |
发明人 |
TILLIB SERGEJ VLADIMIROVICH;SHMAROV MAKSIM MIKHAJLOVICH;IVANOVA TAT'JANA IL'INICHNA;RUTOVSKAJA MARINA VLADIMIROVNA;VASIL'EV LEV ANATOL'EVICH;GRIBOVA IRINA JUR'EVNA;SEDOVA ELENA SERGEEVNA;LYSENKO ANDREJ ALEKSANDROVICH;TUTYKHINA IRINA LEONIDOVNA;LOGUNOV DENIS JUR'EVICH;ALEKSEEVA SVETLANA VIKTOROVNA;OSIPOVA GALINA LEONIDOVNA;AVDEEV SERGEJ NIKOLAEVICH;SAMSONOVA MARIJA VIKTOROVNA;CHERNJAEV ANDREJ L'VOVICH;NARODITSKIJ BORIS SAVEL'EVICH;GINTSBURG ALEKSANDR LEONIDOVICH;CHUCHALIN ALEKSANDR GRIGOR'EVICH |
分类号 |
C07K16/10;A61K39/42;A61P31/16;C12N15/12;C12N15/63 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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