| 发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY |
| 摘要 |
PROBLEM TO BE SOLVED: To provide compounds capable of modulating Ire1 activity useful for treating diseases caused by enhanced Ire1 activity such as cancers, inflammatory diseases and autoimmune diseases, and diseases caused by reduced Ire1 activity such as cystic fibrosis, retinitis pigmentosa, diabetes and neurodegenerative diseases.SOLUTION: Compounds capable of modulating Ire1 activity represented by the formula in the figure are used in the treatment of the diseases. |
| 申请公布号 |
JP2015017099(A) |
申请公布日期 |
2015.01.29 |
| 申请号 |
JP20140165200 |
申请日期 |
2014.08.14 |
| 申请人 |
REGENTS OF THE UNIV OF CALIFORNIA |
发明人 |
PETER WALTER;ALEXEI KORENNYKH;KEVAN M SHOKAT;ZHANG CHAO;JANET FINER-MOORE;ROBERT STROUD;PASCAL EGEA;ANDREI KOROSTELEV;ARVIN DAR |
| 分类号 |
C07D403/12;A61K31/404;A61K31/506;A61P3/10;A61P25/00;A61P25/02;A61P25/14;A61P25/26;A61P25/28;A61P27/02;A61P29/00;A61P35/00;A61P37/06;A61P43/00;C07D403/14;C07D409/14;C07D417/14;C12N5/071;C12N5/09;G01N33/15;G01N33/50;G01N33/542 |
主分类号 |
C07D403/12 |
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