USES FOR AND ARTICLE OF MANUFACTURE INCLUDING HER2 DIMERIZATION INHIBITOR PERTUZUMAB

摘要

The present application describes uses for and articles of manufacture including Pertuzumab a first in class HER2 dimerization inhibitor. In particular the application describes methods for extending progression free survival in a HER2 positive breast cancer patient population; combining two HER2 antibodies to treat HER2 positive cancer without increasing cardiac toxicity; treating early stage HER2 positive breast cancer; treating HER2 positive cancer by co administering a mixture of Pertuzumab and Trastuzumab from the same intravenous bag; treating HER2 positive metastatic gastric cancer; treating HER2 positive breast cancer with Pertuzumab Trastuzumab and Vinorelbine; treating HER2 positive breast cancer with Pertuzumab Trastuzumab and aromatase inhibitor; and treating low HER3 ovarian primary peritoneal or fallopian tube cancer. It also describes an article of manufacture comprising a vial with Pertuzumab therein and a package insert providing safety and/or efficacy data thereon; a method of making the article of manufacture; and a method of ensuring safe and effective use of Pertuzumab related thereto. In addition the application describes an intravenous (IV) bag containing a stable mixture of Pertuzumab and Trastuzumab suitable for administration to a cancer patient.