BICYCLIC HETEROCYCLIC COMPOUND

摘要

[Problem] To provide a compound useful as the active ingredient in a drug composition for treating diseases to which 11ß hydroxysteroid dehydrogenase type 1 contributes such as dementia schizophrenia depression pain (particularly neuropathic pain and fibromyalgia) diabetes (particularly type 2 diabetes) and insulin resistance. [Solution] It was discovered that a bicyclic heterocyclic compound substituted with an acylamino group such as a (hetero)aroylamino group (the bicyclic heterocycle being formed by condensing a cyclohexane ring and a 5 or 6 membered monocyclic heterocycle having only a nitrogen atom as the heteroatom) or a pharmaceutically acceptable salt thereof has a superior selective inhibitory action with respect to 11ß HSD1. Thus the bicyclic heterocyclic compound can be used in the treatment of dementia schizophrenia depression pain (particularly neuropathic pain and fibromyalgia) diabetes (particularly type 2 diabetes) insulin resistance and the like