Tetracycline compositions

摘要

The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.

主权项

1. A method of treating a bacterial infection in a subject, wherein the method consists of:
administering a therapeutically effective amount of a composition to a subject in need thereof via an intravenous route of administration, wherein the composition consists of an aqueous solution consisting of minocycline or a salt thereof, a salt that comprises a magnesium cation, and a base, wherein the molar ratio of magnesium cation to minocycline is greater than about 4:1, and wherein the composition has a pH that is no less than 4 and no greater than 6, whereby injection site hemolysis of red blood cells is reduced relative to intravenous administration of a composition that does not include magnesium.