Indolealkylamino-withasteroid conjugates and method of use

摘要

A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

主权项

1. An isolated compound of Formula (I), or a salt thereof: wherein R1 is selected from the group consisting of hydrogen, (C1-C3)-alkyl, hydroxyl, and (C1-C4)-alkoxy; wherein R2 is hydrogen or (C1-C3)-alkyl; wherein R3 is hydrogen or hydroxyl; and wherein represents a single or a double bond, provided that when R2 is hydrogen, R1 is not hydrogen or 5-methoxy.