Use of lanostane and <i>Poria </i>extract in treating diabetes

摘要

A pharmaceutical composition for treating diabetes is provided in this invention. The composition contains a lanostane compound as a potent component. A suitable source of the lanostane compound is a Poria extract from metabolite, sclerotium, or fermentation product of Poria cocos (Schw) Wolf. The Poria extract contains 1-60% of the lanostane compounds by weight of the extract, and is devoid of secolanostane.

主权项

1. A method of treating type I diabetes, comprising administering to a mammal in need thereof an effective amount of a lanostane compound of the following formula (I), or a pharmaceutically acceptable salt thereof, said lanostane compound being the only active compound administered in the method for treating type I diabetes in the mammal, wherein R1 is either —H or —CH3; R2 is —OCOCH3, ═O, or —OH; R3 is —H or —OH; R4 is —C(═CH2)—C(CH3)2Ra, wherein Ra is either —H or —OH, or —CH═C(CH3)Rb, wherein Rb is —CH3 or —CH2OH; R5 is either —H or —OH, and R6 is either —CH3 or —CH2OH.