| 发明名称 |
REPLICATING RECOMBINANT ADENOVIRUS VECTORS, COMPOSITIONS, AND METHODS OF USE THEREOF |
| 摘要 |
Replicating recombinant adenovirus vectors derived from human adenovirus serotype 26 or human adenovirus serotype 35 are described. The replicating recombinant adenovirus vectors have attenuated replicative capacity as compared to that of the corresponding wild-type adenovirus. They can be used for stable expression of heterologous genes in vivo. Also described are compositions and methods of using these recombinant adenovirus vectors to induce an immune response in a subject, and vaccinate a subject against an immunogenic human immunodeficiency virus (HIV) infection. |
| 申请公布号 |
US2015246112(A1) |
申请公布日期 |
2015.09.03 |
| 申请号 |
US201514632433 |
申请日期 |
2015.02.26 |
| 申请人 |
Beth Israel Deaconess Medical Center, Inc. ;Crucell Holland B.V. |
发明人 |
BAROUCH Dan;ABBINK Peter |
| 分类号 |
A61K39/21;C12N7/00 |
主分类号 |
A61K39/21 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A replicating recombinant adenovirus vector, comprising a recombinant adenovirus genome having:
(a) a promoter operably linked to a heterologous nucleic acid sequence; (b) a functional E1 coding region; (c) a deletion in the E3 coding region; and (d) a deletion in the E4 coding region, provided that E4 open reading frame 6/7 is not deleted, wherein the adenovirus genome is human adenovirus serotype 26 or 35 genome. |
| 地址 |
Boston MA US |
