PHARMACEUTICAL COMPOSITION WITH ANTIMICROBIAL ACTIVITY FOR PARENTERAL USE, PROCESS FOR PREPARING SAME

摘要

The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antibacterial preparations for parenteral use, said preparations having increased therapeutic effectiveness in the treatment of severe forms of infectious inflammatory diseases. The proposed pharmaceutical composition comprises a complex (beta-lactam antibiotic+phosphomycin) and highly dispersed nano-structured silicon dioxide as the active substance. The claimed process for preparing the pharmaceutical composition consists in mixing the complex (beta-lactam antibiotic+phosphomycin) with the highly dispersed nano-structured silicon dioxide in a weight ratio of 10:1 to 75:1 by weight, respectively, and subjecting the mixture produced to mechanical processing by means of impact-abrading actions to increase the finely dispersed fraction portion. The mixture produced is used for preparing injection solutions.