发明名称 |
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE. |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula (I-A) or a pharmaceutically acceptable salt, wherein the variables are as defined herein. |
申请公布号 |
MX2015007101(A) |
申请公布日期 |
2015.09.29 |
申请号 |
MX20150007101 |
申请日期 |
2013.12.06 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
PIERRE-HENRI STORCK;JOANNE PINDER;DAVID KAY;JEAN-DAMIEN CHARRIER;STEVEN DURRANT;JUAN-MIGUEL JIMENEZ;DAMIEN FRAYSSE;DEAN BOYALL;HEATHER TWIN;RONALD KNEGTEL;JOHN STUDLEY;MANINDER PANESAR;NADIA AHMAD;CHRIS DAVIS;REBECCA DAVIS;GORKA ETXEBARRIA I JARDI;DONALD MIDDLETON;MICHAEL ODONNELL;FRANCOISE PIERARD;DAVID SHAW |
分类号 |
C07D487/04;A61K31/495;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|