Hydrogel implants with varying degrees of crosslinking

摘要

The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

主权项

1. A method of forming an implant comprising:
contacting a first reactive precursor with a second reactive precursor and an initiated precursor comprising at least one vinyl group; crosslinking the first reactive precursor and the second reactive precursor to form a first hydrogel; and exposing a surface of the first hydrogel to an initiator to initiate crosslinking of the initiated precursor to form a second hydrogel as a barrier layer over at least a portion of the surface of the first hydrogel.