COMPOSITIONS AND METHODS FOR IMPROVING GLUCOSE UPTAKE

摘要

A compound includes the structure of general Formula (II), pharmaceutically acceptable salts thereof, and/or solvates thereof: wherein R1, R2, R3, are independently selected from the group consisting of null, hydroxy, alkoxy, and halo, or R1 and R2 taken together form a cyclic boronate ester and R3 is null; wherein when four bonds to boron are present, boron bears a formal negative charge and the structure further comprises a countercation that is potassium or sodium, X1, X2, X3, and X4 are independently selected from the group consisting of O, CH, and N, with the proviso that no more than two of combined O and N are selected, and Z is selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, and halogen, any of which may be optionally substituted. Such compounds can increase glucose uptake by cells and preferably do not substantially increase adipogenesis.

主权项

1. A compound comprising the structure of general Formula II pharmaceutically acceptable salts thereof, and/or solvates thereof: wherein R1 and R2 are independently selected from the group consisting of hydroxy, alkoxy, and halo, and R3 is selected from the group consisting of null, hydroxy, alkoxy, and halo, or R1 and R2 taken together with the boron atom form a cyclic boronate ester and R3 is null, wherein when four bonds to boron are present, boron bears a formal negative charge and the structure further comprises a countercation selected from the group consisting of potassium and sodium; the ring atoms at X1, X2, X3, and X4 are independently selected from the group consisting of O, C, and N, with the proviso that no more than two of X1, X2, X3, and X4 are O or N; and Z is selected from the group consisting of null, alkyl, aryl, heteroaryl, and halogen, any of which may be optionally substituted and any carbon atom at X1, X2, X3, and X4 that is not bonded to the group Z is bonded to hydrogen.