The invention provides antibodies that specifically bind to PD-Ll and fusion molecules comprising PD-Ll binding proteins constructed with an IL15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-Ll -mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.
申请公布号
WO2015109124(A3)
申请公布日期
2015.09.24
申请号
WO2015US11657
申请日期
2015.01.15
申请人
KADMON CORPORATION, LLC
发明人
WAKSAL, SAMUEL, D.;ZHU, ZHENPING;WU, YAN;MARTOMO, STELLA, A.;ZHONG, ZHAOJING;LU, DAN