| 发明名称 |
MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION |
| 摘要 |
The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject. |
| 申请公布号 |
US2015265672(A1) |
申请公布日期 |
2015.09.24 |
| 申请号 |
US201314435675 |
申请日期 |
2013.05.31 |
| 申请人 |
GUO Ju-Tao;CHANG Jinhong;BLOCK Timothy M.;KINNEY William A. |
发明人 |
Guo Ju-Tao;Chang Jinhong;Block Timothy M.;Kinney William A.;Almond Harold R. |
| 分类号 |
A61K38/12;C07K5/12;A61K45/06 |
主分类号 |
A61K38/12 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of modulating cccDNA transcription of hepatitis B in a subject comprising administering to said subject an inhibitor of histone deacetylace activity. |
| 地址 |
Lansdale PA US |
