Devices and Methods for Noninvasive Measurement of Intracranial Pressure

摘要

Provided are systems and methods for noninvasively assessing intracranial pressure by controllably applanating at least a portion of a subject's ocular globe so as to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, as well as methods of assessing intracranial pressure that are based, at least in part, on the degree of papilledema, if any, present in the subject.

主权项

1. A system, comprising:
an applanator configured to controllably applanate at least a portion of the ocular globe of a subject, a first image collector configured to collect light reflected from an intraocular blood vessel of the subject; and an illumination train configured to direct light through an ophthalmic component to the intraocular blood vessel of the subject and to direct light reflected from the intraocular blood vessel to the image collector. the system being configured to, during operation, record retinal fundus images, score features of the optic disc using image processing algorithms, or both, the system being configured to compare feature scores to a database of images so as to grade papilledma, if present, according the Modified Frisén Scale.