IMPROVED CHROMATOGRAPHY RESIN, AND METHODS AND DEVICES RELATED THERETO

摘要

The invention relates to the field of analytical and preparative chemistry. Among others, it relates to an improved chromatographic resin and to means and methods involving use of the resin for the (on-line) clean up of complex test samples, such as biological samples. Provided is a chromatographic resin comprising a rigid polymer that is functionalized with at least one ligand capable of binding to a molecule of interest, wherein said ligand is covalently attached to the polymer via a small hydrophilic moiety based on a compound having 1-10 C-atoms and comprising a multiplicity of hydrophilic groups.