| 摘要 |
TRPV3 agonists, e.g., camphor, camphor-oil which contain monoterpene constitutents, 2-APB and derivatives thereof arrest human keratinocyte proliferation and promote differentiation. Methods are provided for diagnosing and treating or preventing keratinocyte-derived lesions, e.g., SCC, (including high-risk forms), non-melanoma skin cancers (including high-risk forms), and actinic keratinosis ("AK") by administering to an afflicted subject a therapeutically effective amount of one or more TRPV3 agonists or derivatives thereof. Pharmaceutical compositions that contain therapeutically effective amounts of one or more TRPV3 agonists or derivatives thereof are also contemplated. |
