| 摘要 |
<p>One aspect of the present invention relates to a method for the transition metal (e.g., Cu(I)) mediated amidation of C-H bonds using electron-rich aliphatic azides. In certain embodiments, the methods are useful for the C-H insertion of nitrenes generated and stabilized by a beta-diketiminato metal catalyst. In certain embodiments, said nitrenes are generated from organoazides, or by oxidation of the corresponding amine. Another aspect of the present invention relates to olefin aziridination using said beta-diketiminato metal catalysts. In addition, the methods of the present invention include stereoselective C-H bond aminations and olefin aziridinatons. In certain embodiments, the methods are conducted in an aerobic environment. In certain embodiments, the present invention relates to the use of O2 as an oxidant, wherein water is the byproduct of oxidation; this fact avoids the generation of toxic byproducts and renders the methods atom economical.</p> |
