发明名称 |
COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS |
摘要 |
<p>The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.</p> |
申请公布号 |
PT2034985(E) |
申请公布日期 |
2015.09.23 |
申请号 |
PT20070803849T |
申请日期 |
2007.07.05 |
申请人 |
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE;UNIVERSITÉ D`AIX-MARSEILLE;ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES (AFM);UNIVERSIDAD DE OVIEDO |
发明人 |
NICOLAS LEVY;PIERRE CAU;CARLOS LOPEZ-OTIN |
分类号 |
A61K31/22;A61K31/675;A61P17/00;A61P43/00 |
主分类号 |
A61K31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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