Oligomeric compounds and compositions for use in modulation of small non-coding RNAs

摘要

Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

主权项

1. A double-stranded miRNA mimic comprising a first strand and a second strand, wherein the first strand and the second strand each consists of 17 to 25 linked nucleosides, wherein
a) the first strand comprises a nucleobase sequence identical to at least 17 contiguous nucleobases of the nucleobase sequence of a mature miRNA; b) the second strand comprises a nucleobase sequence that is at least 90% complementary to the nucleobase sequence of the first strand that is identical to the nucleobase sequence of the mature miRNA; c) the second strand comprises at least one nucleoside with a modified sugar moiety.