| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to anti-tumour compounds: 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-idarubicin, 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-daunorubicin, 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-carminomycin and 3'-deamino-3"-4'-anhydro-[2"(S)-ethoxy-3"(R)-hydroxy-4"-morpholinyl]-doxorubicin, their pharmaceutically acceptable acid addition salts and a method of obtaining formulacompound or its pharmaceutically acceptable acid addition salts by the interaction of cyanuric chloride with an N-oxide derivative of formula,where Ris H, OH or OCH;or OH, Ris H or C-C-alkoxy.EFFECT: claimed are novel effective anti-tumour medications and methods of obtaining thereof, making it possible to obtain formula (I) compound with good output and purity.7 cl, 1 ex, 1 tbl |
