3 PHENYL ISOQUINOLIN 1(2H) ONE DERIVATIVES AS PARP 1 INHIBITORS

摘要

There are provided substituted 3 phenyl isoquinolin 1(2H) one derivatives which selectively inhibit the activity of poly(ADP ribose) polymerase PARP 1 with respect to poly(ADP ribose) polymerase PARP 2. The compounds of the present invention are therefore useful in treating diseases such as cancer cardiovascular diseases central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds pharmaceutical compositions comprising these compounds and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.