Nanocarriers And Their Processing For Diagnostics And Therapeutics

摘要

The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.

主权项

1. A system for selective drug delivery to a bodily tissue comprising a rosette nanopiece composition comprising a cargo compound,
wherein a positively-charged nanopiece composition with net positive charge at pH 7-7.5 localizes or penetrates a negatively-charged tissue; wherein a negatively-charged or weakly positively-charged nanopiece composition with net negative charge or weak positive charge at pH 7-7.5 localizes or penetrates a positively-charged tissue.