METHODS OF USING FEXARAMINE AND AGENTS THAT INCREASE SYMPATHETIC NERVOUS SYSTEM ACTIVITY TO PROMOTE BROWNING OF WHITE ADIPOSE TISSUE

摘要

Provided are methods of promoting browning of white adipose tissue (WAT) in a subject. Such methods can include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of fexaramine in combination with a therapeutically effective amount of a compound that mimics or increases sympathetic nervous system activity (e.g., one or more beta-adrenergic agonists and/or compounds that increase epinephrine secretion).

主权项

1. A method of promoting browning of white adipose tissue (WAT), comprising:
administering a therapeutically effective amount of fexaramine to a gastrointestinal tract of a subject; and administering a therapeutically effective amount of one or more compounds that mimic or increase sympathetic nervous system activity, thereby promoting browning of white adipose tissue (WAT).